Navarrini G, Russo C, Baldoni F, Boaron M
J Chir (Paris). 1981 Jul-Aug;118(6-7):401-6.
A biliopancreatic bypass operation has been used to treat obese patients since June 1978, and 10 women have been followed-up for over a year. Biliopancreatic shunts reduce food absorption by eliminating enzymatic and biliary secretion activity in the intestinal lumen. Bodyweight loss was satisfactory, was proportional to excess weight, and was evaluated as being a mean of 33.1 kg. The constant and sometimes dramatic diarrhea provoked by conventional jejuno-ileal bypass operations was not observed. Hepatic steatosis, frequently present to varying degrees, was never made worse : in one case it even disappeared completely, while in another case biological tests conducted one year after operation showed considerable regression. Neither severe complications nor mortality were reported in this series.
自1978年6月起，胆胰转流手术被用于治疗肥胖患者，已有10名女性接受了超过一年的随访。胆胰分流通过消除肠腔内的酶和胆汁分泌活性来减少食物吸收。体重减轻情况令人满意，与超重成正比，平均减轻了33.1千克。未观察到传统空肠回肠分流手术常引发的持续性且有时很严重的腹泻。经常不同程度存在的肝脂肪变性从未加重：1例甚至完全消失，另1例术后1年进行的生物学检查显示有明显好转。该系列中未报告严重并发症和死亡情况。
