Kofler R, Tabarelli M, Berger P, Wick G
J Reprod Immunol. 1981 Sep;3(4):219-25. doi: 10.1016/0165-0378(81)90043-7.
The effect of suppression of prolactin (PRL) serum levels on early pregnancy and lactation in the rat by means of either bromergocryptine (BEC) or rabbit antiserum to rat PRL has been examined. BEC terminated early pregnancy when given on any day from 1 to 6 and significantly impaired lactation performance when injected during the lactation period. Antibodies against rat PRI, however, showed no effect on either early pregnancy or lactation, although the sera of the treated rats contained free PRL antibodies as evidence for sufficient dosage of antiserum. This finding can be explained in two ways: either the antibodies are not able to neutralize the biological activity of the bound PRL, or the effect of BEC is not mediated by PRL-suppression alone but requires a second component not provided by the specific antiserum.
通过溴隐亭（BEC）或兔抗大鼠催乳素血清抑制大鼠血清催乳素（PRL）水平对大鼠早期妊娠和泌乳的影响已得到研究。在妊娠第1天至第6天的任何一天给予BEC均可终止早期妊娠，且在泌乳期注射时会显著损害泌乳性能。然而，抗大鼠PRL抗体对早期妊娠或泌乳均无影响，尽管处理过的大鼠血清中含有游离PRL抗体，表明抗血清剂量充足。这一发现可以从两个方面来解释：要么抗体无法中和结合型PRL的生物活性，要么BEC的作用并非仅由PRL抑制介导，而是需要特定抗血清未提供的第二种成分。
