Larsson M, Nylander G, Ohman U
J Trauma. 1981 Oct;21(10):870-7. doi: 10.1097/00005373-198110000-00007.
Anesthetized rats were submitted to a standardized hemorrhage to 40 mm Hg by withdrawing 35 to 40% of the total blood volume. The plasma water and the extracellular fluid volumes of the whole animal and selected tissues were estimated with 125 I human serum albumin and 51Cr EDTA, respectively, after recovery periods of 10 and 90 minutes. The plasma water volume of the whole animal decreased, but approximately 50% of the shed plasma water was restored within 10 minutes after the hemorrhage. The extracellular fluid volume of the whole animal did not change significantly after hemorrhage, whereas this fluid compartment was regionally reduced in the liver, spleen, and subcutaneous fat after a 10-min recovery period but only in the liver after a 90-min recovery period.
将麻醉的大鼠通过抽取35%至40%的全血容量使其血压标准化降至40 mmHg。在10分钟和90分钟的恢复期后，分别用125I人血清白蛋白和51Cr EDTA估计全动物和选定组织的血浆水量和细胞外液量。全动物的血浆水量减少，但出血后10分钟内约50%流失的血浆水得以恢复。出血后全动物的细胞外液量没有显著变化，而在10分钟恢复期后，该体液区室在肝脏、脾脏和皮下脂肪中区域性减少，但在90分钟恢复期后仅在肝脏中减少。
