Diehm C, Mörl H, Müller-Bühl U, Schrey A, Grund R
MMW Munch Med Wochenschr. 1981 Sep 25;123(39):1458-62.
A fixed combination preparation consisting of a betablocker and diuretics was tested in 25 outpatients suffering from essential hypertension grades I and II (WHO). The raised blood pressures of the placebo phase fell highly significantly to normal values in th course of the 8 weeks' treatment. The ergometric load testing under standardized conditions showed a significant reduction of blood pressure increase, a significant rise in load capacity, and a decrease in the pressure rate product. Apart from the increase in serum acid in one case, no clinically relevant changes in the laboratory values were observed. Tolerance was good. The side effects mentioned by 10 patients were mild and did not influence the course of treatment. Patient compliance, measured twice in th course of the trial by means of urine fluorescence, was very high (95%).
一种由β受体阻滞剂和利尿剂组成的固定复方制剂在25例患有I级和II级原发性高血压（世界卫生组织标准）的门诊患者中进行了测试。在8周的治疗过程中，安慰剂阶段升高的血压显著降至正常水平。在标准化条件下进行的测力计负荷测试显示，血压升高显著降低，负荷能力显著提高，压力速率乘积降低。除1例血清酸升高外，未观察到实验室值有临床相关变化。耐受性良好。10例患者提及的副作用轻微，未影响治疗进程。在试验过程中通过尿液荧光法测量了两次患者依从性，结果非常高（95%）。
