Smyth J A, Tabachnik E, Duncan W J, Reilly B J, Levison H
Pediatrics. 1981 Sep;68(3):336-40.
Nine children with bronchopulmonary dysplasia were studied at a mean age of 8.4 years. Persistent respiratory symptoms were common. Pulmonary function tests demonstrated airway obstruction and abnormal blood gas levels in most. In six of eight children results of methacholine challenge tests were positive, indicating bronchial hyperreactivity. Abnormal chest radiographs persisted in eight children. The bronchial hyperreactivity is a likely consequence of airway damage in infancy and is the probable reason for episodic wheezing in the early years of life. Improvement in expiratory flow rates following bronchodilator inhalation suggests that such therapy may improve function in these children.
对9名支气管肺发育不良的儿童进行了研究，平均年龄为8.4岁。持续性呼吸道症状很常见。肺功能测试显示大多数儿童存在气道阻塞和异常血气水平。在8名儿童中的6名中，乙酰甲胆碱激发试验结果呈阳性，表明存在支气管高反应性。8名儿童的胸部X光片仍异常。支气管高反应性可能是婴儿期气道损伤的结果，也是生命早期发作性喘息的可能原因。吸入支气管扩张剂后呼气流量率的改善表明，这种治疗可能改善这些儿童的功能。
