Rosenfeldt F L, Glover J R, Marossy D
Thorax. 1981 Apr;36(4):278-81. doi: 10.1136/thx.36.4.278.
Systemic side-effects during irrigation of body cavities with the antiseptic noxythiolin (Noxyflex) have not previously been reported. In two patients undergoing intrapleural lavage with 1% noxythiolin, anorexia and nausea with or without vomiting were observed which suggested systemic absorption. This was confirmed by chemical assays of serum from these patients. The process of absorption was studied in rabbits by injection of noxythiolin into the pleural or peritoneal cavity. Serum levels reached a peak at one to two hours indicating rapid entry into the bloodstream, declined slowly over seven hours, and reached zero before 24 hours. Although side-effects resulted from systemic absorption of noxythiolin during irrigation of the pleural cavity, they were mild and did not contra-indicate the use of noxythiolin as an irrigant. Awareness of the mechanism of side-effects of noxythiolin provides a rational basis for management of symptoms through reduction of the volume or frequency of irrigation.
此前尚未有关于使用防腐剂硝羟喹啉（Noxyflex）冲洗体腔时出现全身副作用的报道。在两名接受1%硝羟喹啉胸腔灌洗的患者中，观察到了厌食和伴有或不伴有呕吐的恶心，这提示有全身吸收。对这些患者血清的化学分析证实了这一点。通过将硝羟喹啉注入兔的胸腔或腹腔来研究吸收过程。血清水平在1至2小时达到峰值，表明其迅速进入血液循环，在7小时内缓慢下降，并在24小时前降至零。虽然胸腔灌洗期间硝羟喹啉的全身吸收导致了副作用，但这些副作用很轻微，并不构成使用硝羟喹啉作为灌洗剂的禁忌。了解硝羟喹啉副作用的机制为通过减少冲洗量或冲洗频率来处理症状提供了合理依据。
