Freund H R
Arch Surg. 1981 Sep;116(9):1220-1. doi: 10.1001/archsurg.1981.01380210088018.
Thrombosis of large veins during total parenteral nutrition (TPN) is considered uncommon. Recently, clinical and phlebographic evidence of large-vein thrombosis were encountered in five patients among 200 consecutive patients receiving TPN. The symptoms, signs, and phlebographic findings occurred within one to two days, sometimes as early as a few hours after cannulation. It is suggested that thrombosis of large veins during TPN is not uncommon and is the result of chemical phlebothrombosis due to a hypersensitivity reaction of the venous wall to the polyvinyl catheter material. Early removal of the offending catheter is advocated.
全胃肠外营养（TPN）期间大静脉血栓形成被认为并不常见。最近，在连续200例接受TPN治疗的患者中，有5例出现了大静脉血栓形成的临床和静脉造影证据。症状、体征和静脉造影表现出现在插管后1至2天内，有时早在插管后数小时就出现。提示TPN期间大静脉血栓形成并不少见，是静脉壁对聚乙烯导管材料过敏反应导致的化学性静脉血栓形成的结果。主张尽早拔除有问题的导管。
