de Marco P, Tassinari C A
Epilepsia. 1981 Oct;22(5):569-75. doi: 10.1111/j.1528-1157.1981.tb04128.x.
In a population of 15,000 children it was found that tactile stimulation, mainly tapping on the soles or heels of the feet, could elicit high-voltage evoked potentials in the EEGs of 1% of them. A longitudinal study of 16 of these patients showed a stereotyped electroclinical evolution. At first, only extreme somatosensory evoked potential (ESEPs) were observed in nonepileptic children with normal EEG records (first period). Then, after a variable delay, spontaneous EEG abnormalities appeared, first only during sleep, and then also during wakefulness, usually as spikes involving the same parietal and midline regions where the ESEPs were evident (second and third periods). Seizures then began (fourth period) within 5 months to 2 years after the appearance of the interictal focal abnormalities. Such seizures were rare, but in some cases they were grouped in bouts that amounted to status epilepticus. The seizures were usually of the partial motor type, with adversion of the head, but infrequently they assumed the tonic-clonic type; they occurred mainly during the daytime. The fits were short-lived, however, and after a year had mostly disappeared, while the ESEPs and spontaneous interictal focal abnormalities sometime persisted for several year before disappearing, too. The subjects were otherwise neurologically and psychologically normal throughout the observation and follow-up period.
在15000名儿童群体中发现，触觉刺激（主要是轻拍脚底或脚跟）能在其中1%的儿童脑电图中诱发高电压诱发电位。对其中16名患者进行的纵向研究显示出一种刻板的电临床演变过程。起初，在脑电图记录正常的非癫痫儿童中仅观察到极体感诱发电位（ESEP）（第一阶段）。然后，经过一段可变的延迟后，脑电图出现自发异常，起初仅在睡眠期间出现，随后在清醒时也出现，通常表现为棘波，涉及ESEP明显的相同顶叶和中线区域（第二和第三阶段）。发作随后在发作间期局灶性异常出现后的5个月至2年开始（第四阶段）。这种发作很少见，但在某些情况下会成簇发作，达到癫痫持续状态。发作通常为部分运动型，伴有头部扭转，但很少为强直阵挛型；主要在白天发作。然而，发作持续时间较短，一年后大多消失，而ESEP和发作间期自发局灶性异常有时在消失前也会持续数年。在整个观察和随访期间，这些受试者在神经和心理方面其他情况正常。
