促黑素细胞激素增强因子（MPF）可增强促黑素细胞激素（MSH）诱导的毛囊黑素细胞的黑素生成。
Melanotrophin-potentiating factor (MPF) potentiates MSH-induced melanogenesis in hair follicle melanocytes.
作者信息
Logan A, Carter R J, Shuster S, Thody A J, Weatherhead B
出版信息
Peptides. 1981 Summer;2(2):121-3. doi: 10.1016/s0196-9781(81)80022-8.
Melanotrophin-potentiating factor (MPF) is a fragment of human beta-lipotrophin (LPH 88-91) which potentiates the action of alpha-MSH on Anolis skin. In the present study, we investigated the effect of MPF on MSH-induced melanogenesis. Pooled hair follicle scrapings from Siberian hamsters (Phodopus sungorus) were incubated for 48 hours with or without alpha-MSH and/or MPF. Melanogenesis was monitored by measuring tyrosinase activity and melanin accumulation. 10-8 M MPF potentiated the effect of no effect on melanogenesis, but 10-9 to 10-7 M alpha-MSH caused a dose-related increase. 10-8 M MPF potentiated the effect of each dose of alpha-MSH. Thus MPF potentiated MSH action on mammalian melanogenesis as well as on reptilian melanosome dispersion. Although each of these processes involve different intracellular responses the receptor mechanisms involved in each may therefore be the same.
促黑素增强因子（MPF）是人类β-促脂素（LPH 88-91）的一个片段，它能增强α-促黑素细胞激素对安乐蜥皮肤的作用。在本研究中，我们调查了MPF对促黑素细胞激素诱导的黑色素生成的影响。将来自西伯利亚仓鼠（黑线毛足鼠）的合并毛囊刮屑在有或没有α-促黑素细胞激素和/或MPF的情况下孵育48小时。通过测量酪氨酸酶活性和黑色素积累来监测黑色素生成。10^-8 M的MPF对黑色素生成没有影响，但10^-9至10^-7 M的α-促黑素细胞激素会引起剂量相关的增加。10^-8 M的MPF增强了每种剂量的α-促黑素细胞激素的作用。因此，MPF增强了促黑素细胞激素对哺乳动物黑色素生成以及对爬行动物黑素体分散的作用。尽管这些过程中的每一个都涉及不同的细胞内反应，但因此每个过程中涉及的受体机制可能是相同的。
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