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对类固醇难治的急性免疫性血小板减少症患者输注载有长春新碱的血小板:脾切除术的替代方法。

Infusion of vincristine-loaded platelets in acute ITP refractory to steroids: an alternative to splenectomy.

作者信息

Nenci G G, Agnelli G, De Cunto M, Gresele P

出版信息

Acta Haematol. 1981;66(2):117-21. doi: 10.1159/000207108.

DOI:10.1159/000207108
PMID:6794311
Abstract

Three infusions of vincristine-loaded platelets were carried out in a young man with acute idiopathic thrombocytopenic purpura (ITP) refractory to steroids. This procedure, used until now only for chronic refractory ITP, insured a remission without side effects. After 2 years of follow-up the patient has not had relapse. A potentially dangerous splenectomy was thus avoided in a phase of the disease in which a spontaneous remission was still very probable.

摘要

对一名患有急性特发性血小板减少性紫癜(ITP)且对类固醇治疗无效的年轻男性进行了三次加载长春新碱的血小板输注。该程序此前仅用于慢性难治性ITP,确保了缓解且无副作用。经过2年的随访,患者未复发。因此,在疾病的一个阶段避免了可能危险的脾切除术,而此时仍很有可能出现自发缓解。

相似文献

1
Infusion of vincristine-loaded platelets in acute ITP refractory to steroids: an alternative to splenectomy.对类固醇难治的急性免疫性血小板减少症患者输注载有长春新碱的血小板:脾切除术的替代方法。
Acta Haematol. 1981;66(2):117-21. doi: 10.1159/000207108.
2
[Use of vincristine-loaded blood platelets, danazol and gamma globulin in the treatment of patients with idiopathic thrombocytopenic purpura].
Acta Haematol Pol. 1989 Jan-Jun;20(1):65-71.
3
[Therapy of idiopathic thrombocytopenic purpura].
Pediatr Med Chir. 1986 Jan-Feb;8(1):33-7.
4
Low-dose vincristine in the treatment of corticosteroid-refractory idiopathic thrombocytopenic purpura (ITP) in non-splenectomized patients.低剂量长春新碱治疗非脾切除患者中对皮质类固醇难治的特发性血小板减少性紫癜(ITP)
Postgrad Med J. 1980 Oct;56(660):711-4. doi: 10.1136/pgmj.56.660.711.
5
Vincristine as an alternative to splenectomy in severe acute ITP insensitive to steroids.对于对类固醇无反应的严重急性免疫性血小板减少症,长春新碱可作为脾切除术的替代疗法。
Haematologica. 1983 Mar-Apr;68(2):289-90.
6
Vincristine-loaded platelet infusion for treatment of refractory autoimmune hemolytic anemia and chronic immune thrombocytopenia: rethinking old cures.载长春新碱血小板输注治疗难治性自身免疫性溶血性贫血和慢性免疫性血小板减少症:重新审视古老疗法
Am J Hematol. 2006 Jun;81(6):423-5. doi: 10.1002/ajh.20632.
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Childhood idiopathic thrombocytopenic purpura. Aggressive management of life-threatening complications.
JAMA. 1975 May 19;232(7):734-6.
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Idiopathic thrombocytopenic purpura complicating chronic lymphocytic leukemia.特发性血小板减少性紫癜合并慢性淋巴细胞白血病
Arch Intern Med. 1976 Jan;136(1):62-6.
9
[Thrombocytopenias. Therapy of idiopathic thrombopenic purpura (ITP)].
Haematologica. 1979 Oct;64 Suppl:160-75.
10
Slow infusion of vincristine in the treatment of refractory thrombocytopenic purpura.缓慢输注长春新碱治疗难治性血小板减少性紫癜。
Acta Haematol. 1988;80(3):173-4. doi: 10.1159/000205627.

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