Sebag C, Motté G, Pariente P, Davy J M
Arch Mal Coeur Vaiss. 1981 Jun;74(6):705-17.
Splitting of the His potential (H) in sinus rhythm is generally considered to be pathological but its significance during programmed atrial stimulation is not clear. This phenomenon was observed in 10 out of 53 patients aged between 19 and 45 years (average 31.8 years) not suspected of having paroxysmal intranodal block (asymptomatic, sinus rhythm without bundle branch block). Under basal conditions the H and the HV interval (35 to 50 ms; average 41 ms) were normal. Split H was observed with pacing periods of 680 to 885 ms (average 754 ms) and H1 H2 intervals of 325 to 450 ms (average 395 ms). The maximal interval between the split potentials ranged from 80 to 130 ms (average 100 ms). Splitting disappeared at the shortest periods when variable pacing cycles were used. The response to regular atrial pacing up to 150 bpm (10 cases) and to Ajmaline (1 mg/Kg) (4 cases) was normal. All patients but one were followed up to 10 to 41 months (average 21.4 months); the clinical and ECG parameters remained stable during this period. The presence of fragmented potentials between the atrial and ventricular complexes during programmed atrial stimulation may pose a difficult diagnosis problem, especially with respect to delayed atrial potentials. Splitting of the H is generally attributed to dispersion of the depolarisation wave front in the His bundle due to the persistence of the functional refractory state. Other mechanisms, especially longitudinal dissociation of the His bundle, may be discussed. From a prognostic point of view, this finding does not seem to carry more serious implications than simple lengthening of the HV interval or intranodal conduction delay, phenomena usually considered to be non-pathological.
窦性心律时希氏束电位(H)分裂一般被认为是病理性的,但其在程控心房刺激时的意义尚不清楚。在53例年龄在19至45岁(平均31.8岁)、未怀疑有阵发性结内阻滞(无症状、窦性心律且无束支阻滞)的患者中,有10例观察到了这种现象。在基础状态下,H和HV间期(35至50毫秒;平均41毫秒)正常。在起搏周期为680至885毫秒(平均754毫秒)、H1 - H2间期为325至450毫秒(平均395毫秒)时观察到H分裂。分裂电位之间的最大间期为80至130毫秒(平均100毫秒)。当使用可变起搏周期时,在最短周期时分裂消失。对高达150次/分的规则心房起搏(10例)和对阿义马林(1毫克/千克)(4例)的反应正常。除1例外,所有患者均随访了10至41个月(平均21.4个月);在此期间临床和心电图参数保持稳定。程控心房刺激时心房和心室复合波之间出现碎裂电位可能会带来诊断难题,尤其是对于延迟的心房电位。H分裂一般归因于希氏束内去极化波前的离散,这是由于功能性不应期的持续存在。也可以讨论其他机制,特别是希氏束的纵向分离。从预后的角度来看,这一发现似乎并不比通常被认为非病理性的单纯HV间期延长或结内传导延迟更具严重意义。