雌激素长期治疗致大鼠高催乳素血症后对垂体生长激素、促甲状腺激素、黄体生成素和卵泡刺激素分泌的影响。

Effects on the secretion of pituitary growth hormone, thyroid stimulating hormone, luteinizing hormone and follicle stimulating hormone in rats rendered hyperprolactinaemic by chronic treatment with oestrogen.

作者信息

Smythe G A, Brandstater J F, Vining R F

出版信息

Aust J Biol Sci. 1981;34(3):321-4. doi: 10.1071/bi9810321.

Abstract

The induction of hyperprolactinaemia in the male rat following chronic high-dose oestrogen administration over 3 months was associated with a significant inhibition of the secretion of growth hormone (GH) (P less than 0.02) thyroid stimulating hormone (TSH) (p less than 0.0025), luteinizing hormone (LH) and follicle stimulating hormone (FSH) (both P less than 0.01). Acute, but not chronic, administration of bromocriptine (1 mg/kg) to these hyperprolactinaemic animals had the effect of normalizing the serum levels of GH and TSH but not those of LH or FSH. While the effects observed on GH, TSH, LH and FSH following induction of hyperprolactinaemia are likely to be consequential to brain actions of prolactin, the present data do not exclude the possibility of direct actions of oestrogen itself.

摘要

雄性大鼠经3个月慢性高剂量雌激素给药后出现高催乳素血症，同时生长激素（GH）分泌受到显著抑制（P<0.02），促甲状腺激素（TSH）分泌受到显著抑制（P<0.0025），黄体生成素（LH）和卵泡刺激素（FSH）分泌均受到显著抑制（均为P<0.01）。对这些高催乳素血症动物急性（而非慢性）给予溴隐亭（1mg/kg）可使血清GH和TSH水平恢复正常，但对LH或FSH水平无此作用。虽然高催乳素血症诱导后对GH、TSH、LH和FSH的影响可能是催乳素对脑作用的结果，但目前的数据并不排除雌激素本身直接作用的可能性。