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[从胃黏膜中分离出的多肽及其对胃腺胃蛋白酶生物合成的影响]

[Polypeptides isolated from the gastric mucosa and their effect on pepsin biosynthesis by gastric glands].

作者信息

Storozhuk P G, Bykov I M, Litvinova T N

出版信息

Biull Eksp Biol Med. 1981 Aug;92(8):40-2.

PMID:6794667
Abstract

It was found in experiments on 90 rats that polypeptides A, B and C (with a molecular mass of 2200-2800) isolated from the gastric mucosa have the ability to stimulate pepsin biosynthesis by the gastric glands. Application of the polypeptides did not result in the concurrent rise of proteolytic and milk-curdling activity. Pepsin and trypsin promoted the release from polypeptide B of low-molecular weight peptides which also stimulated pepsin biosynthesis.

摘要

在对90只大鼠进行的实验中发现,从胃黏膜分离出的多肽A、B和C(分子量为2200 - 2800)具有刺激胃腺合成胃蛋白酶的能力。应用这些多肽不会导致蛋白水解活性和凝乳活性同时升高。胃蛋白酶和胰蛋白酶促进了低分子量肽从多肽B的释放,这些低分子量肽也刺激胃蛋白酶的生物合成。

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