Colombo T, Torti L, D'Incalci M
Cancer Chemother Pharmacol. 1981;5(3):201-3. doi: 10.1007/BF00258481.
Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 mu g/ml X min; plasma clearances were 0.042 and 0.027 l . kg(-1) . min(-1), respectively. These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.
测定了静脉注射10毫克/千克和50毫克/千克五甲基三聚氰胺（PMM）的大鼠血浆中PMM及其一些代谢物的浓度。这些剂量后的血浆水平曲线下面积分别为241和1827微克/毫升·分钟；血浆清除率分别为0.042和0.027升·千克⁻¹·分钟⁻¹。这些数据表明，PMM在大鼠体内的药代动力学是剂量依赖性的。N-去甲基化代谢物水平与给药剂量不成比例。
