正常人和肥胖者皮质醇、生长激素及催乳素昼夜变化的同步研究。长期禁食对肥胖的影响。

Simultaneous study of cortisol, growth hormone and prolactin nyctohemeral variations in normal and obese subjects. Influence of prolonged fasting in obesity.

作者信息

Copinschi G, De Laet M H, Brion J P, Leclercq R, L'Hermite M, Robyn C, Virasoro E, Van Cauter E

出版信息

Clin Endocrinol (Oxf). 1978 Jul;9(1):15-26. doi: 10.1111/j.1365-2265.1978.tb03568.x.

DOI:10.1111/j.1365-2265.1978.tb03568.x

Abstract

Hourly integrated concentrations (IC) of growth hormone (GH), prolactin (PRL) and cortisol were determined by a continuous sampling procedure in six obese women, before and at the end of a 12 day fast, and in eight normal controls under basal conditions. Hormonal 24 h IC and nyctohemeral variations were calculated from these data. Nyctohemeral rhythms were investigated by the periodogram method. A significant increase over basal values of 24 h IC of PRL, GH and cortisol was observed at the end of the fasting period. Nyctohemeral variations--but not nyctohemeral rhythm--of IC-GH were found in normal subjects. They were abolished in obese patients under basal conditions but restored during fasting. The circadian rhythm of cortisol was not altered in obesity. A shift of the normal nyctohemeral rhythm of PRL was observed in obese patients, but the normal pattern was restored during fasting.

摘要

通过连续采样程序，测定了6名肥胖女性在禁食12天前和结束时以及8名基础状态下正常对照者的生长激素（GH）、催乳素（PRL）和皮质醇的每小时综合浓度（IC）。根据这些数据计算激素的24小时IC和昼夜变化。通过周期图法研究昼夜节律。在禁食期结束时，观察到PRL、GH和皮质醇的24小时IC较基础值显著升高。在正常受试者中发现了IC-GH的昼夜变化——但不是昼夜节律。在基础状态下肥胖患者中这些变化消失，但在禁食期间恢复。肥胖患者中皮质醇的昼夜节律未改变。在肥胖患者中观察到PRL正常昼夜节律的偏移，但在禁食期间恢复了正常模式。