Langer F, Gross A E, West M, Urovitz E P
Clin Orthop Relat Res. 1978 May(132):155-62.
Joint allotransplantation has been employed in the management of osteoarthritis affecting primarily one compartment of the knee. Biological resurfacing and realignment of the knee has been the goal. The immunological results of six patients posttransplant were studied with the lymphocyte microcytotoxicity test. Definite immunogenicity was demonstrated at an early stage. The sera from the recipients posttransplant was noted to abrogate the in vitro cytotoxicity suggesting the presence of blocking factors. The actual clinical significance of this phenomenon was difficult to judge insofar as no evidence of allograft joint rejection was seen.
同种异体关节移植已被用于治疗主要影响膝关节一个间室的骨关节炎。膝关节的生物性表面置换和重新排列一直是治疗目标。通过淋巴细胞微量细胞毒性试验研究了6例移植后患者的免疫学结果。在早期就证实了明确的免疫原性。观察到移植后受者的血清消除了体外细胞毒性，提示存在封闭因子。鉴于未观察到同种异体关节排斥反应的证据，这种现象的实际临床意义难以判断。
