Bianco J A, Shafer R B
Clin Nucl Med. 1978 May;3(5):176-8. doi: 10.1097/00003072-197805000-00003.
A series of 35 xenon-133 (133Xe) ventilation studies yielded nine cases demonstrating accumulation of activity in the liver. Maximum intrahepatic deposition of radioxenon occurred during the washout phase of the study. In addition to those clinical instances which make this phenomenon possible, i.e., obesity, alcoholic-induced liver steatosis and diabetes mellitus, we found that hyperlipidemia and coronary artery disease also favor xenon-133 localization into the hepatic parenchyma. It is concluded that the lipid avidity of 133Xe facilitates its liver accumulation hyperlipidemic patients and in patients with coronary artery disease, and that this action may be explored to further understand deranged metabolic pathways in the liver of these patients. Hepatic accumulation of 133Xe during ventilation studies must be considered when assessing regional ventilation/perfusion relationships.
一系列35例氙-133（¹³³Xe）通气研究中，有9例显示肝脏出现放射性聚集。放射性氙在肝脏内的最大沉积发生在研究的洗脱期。除了肥胖、酒精性肝脂肪变性和糖尿病等可能导致这种现象的临床情况外，我们发现高脂血症和冠状动脉疾病也有利于¹³³Xe在肝实质内定位。得出的结论是，¹³³Xe对脂质的亲和力促使其在高脂血症患者和冠状动脉疾病患者的肝脏中蓄积，并且可以利用这一作用进一步了解这些患者肝脏中紊乱的代谢途径。在评估局部通气/灌注关系时，必须考虑通气研究期间¹³³Xe在肝脏中的蓄积情况。
