Asatoor A M, Bending M R, Milne M D
Clin Sci Mol Med. 1978 Aug;55(2):205-12. doi: 10.1042/cs0550205.
A study has been made of urinary peptide output in rats before and after production of a Fanconi syndrome induced by a single injection of sodium maleate. There was an unequivocal increase of urinary peptides on the first and second days after the injection, without any detectable change in the concentration of plasma peptides. 2. Similar results were obtained in osteolathyritic rats in which skeletal lesions had been produced by ingestion of beta-aminopropionitrile. 3. The fractional amino acid content of urinary peptides after maleate and beta-aminopropionitrile is shown to be significantly different from that in control animals. 4. Evidence is presented that the increased output of peptides is mainly due to increased renal clearance similar to that previously described for amino acids, glucose and several electrolytes in this type of experimental Fanconi syndrome.
对单次注射马来酸钠诱导产生范科尼综合征前后大鼠的尿肽排出量进行了一项研究。注射后的第一天和第二天尿肽有明确增加，而血浆肽浓度没有任何可检测到的变化。2. 在因摄入β-氨基丙腈而产生骨骼病变的骨软化病大鼠中也得到了类似结果。3. 马来酸钠和β-氨基丙腈处理后尿肽中的氨基酸分数含量显示与对照动物有显著差异。4. 有证据表明，肽排出量增加主要是由于肾脏清除率增加，这与先前在这类实验性范科尼综合征中描述的氨基酸、葡萄糖和几种电解质的情况类似。
