Gordon D
Clin Toxicol. 1978;12(5):563-78. doi: 10.3109/15563657809150031.
Opiate addicts receiving nonmethadone, symptomatic, chemotherapeutic treatment for the abstinence syndrome (at Terros' Opiate Detoxification Program), complained of pains that appeared unrelated to abstinence. The pains reported were primarily lumbosacral pains, joint pains, abdominal cramps, and muscle cramps in the lower extremities. Admission laboratory tests on 150 addicts were used in an attempt to correlate the blood chemistry with the type of pains described. Results of this preliminary screening indicate that a high uric acid level and a low blood urea nitrogen (BUN) may be related in females with joint pains and males with lumbrosacral pains. Values obtained from the nomogram indicate that all addicts have less than 50% of the total serum calcium in ionized form, and the low serum ionized calcium content is associated with abdominal and muscle pains, although 72% of all the addicts studied were within the 3.5 to 4.0 mg range. Hyperproteinemia, low BUN, high uric acid, and low serum ionized calcium were the most significant of the blood chemistry values. Blood glucose levels were not included due to the fact that test were not necessarily fasting results.
在特罗斯戒毒项目中，接受非美沙酮对症化疗治疗戒断综合征的阿片类成瘾者抱怨出现了与戒断无关的疼痛。报告的疼痛主要是腰骶部疼痛、关节疼痛、腹部绞痛和下肢肌肉痉挛。对150名成瘾者进行入院实验室检查，试图将血液化学指标与所描述的疼痛类型联系起来。这项初步筛查的结果表明，高尿酸水平和低血尿素氮（BUN）可能与女性的关节疼痛和男性的腰骶部疼痛有关。从列线图获得的值表明，所有成瘾者的离子化血清钙占总血清钙的比例不到50%，血清离子化钙含量低与腹部和肌肉疼痛有关，尽管所有研究的成瘾者中有72%的人血清离子化钙含量在3.5至4.0毫克范围内。高蛋白血症、低BUN、高尿酸和低血清离子化钙是血液化学指标中最显著的指标。由于检测结果不一定是空腹结果，因此未包括血糖水平。
