[Histochemical demonstration of enzyme activity changes in the regio postcentralis of the mouse brain under the effect of the aging process].

The distribution of some oxidoreductases were investigated in the regio postcentralis of young, adult and senescent mice brains by means of semiquantitative histoenzymatic methods. It was possible to observe a different spread of activities of 1-malate: NAD oxidoreductase (EC 1.1.1.37) and D-glucose-6-phosphate: NADP oxidoreductase (EC 1.1.1.49) in several layers of the regio postcentralis between young and old animals. The enzyme products of 1-glutamate:NAD(P) oxidoreductase (EC 1.4.1.3), 1-alpha-glycerine-3-phosphate:NAD oxidoreductase (EC 1.1.1.8) and D-glucose-6-phosphate:NADP oxidoreductase (EC 1.1.1.49) in the whole area show a decrease after the 20th month of the life, but it exists strain differences. The investigated enzymes of citric acid cycle were not vary in the ageing process.