Demarest K T, Moore K E
J Neural Transm. 1981;52(3):175-87. doi: 10.1007/BF01249602.
Clorgyline (0.3-10 mg/kg, i.p.) inhibited type A monamine oxidase (5-hydroxytryptamine as substrate) but not type B monoamine oxidase (phenylethylamine as substrate) in homogenates of rat striatum and olfactory tubercle; deprenyl (0.3-3 mg/kg, i.p.) inhibited type B but not type A monoamine oxidase in these homogenates. The same doses of clorgyline increased concentrations of dopamine in striatum, and dopamine and norepinephrine in the olfactory tubercle, median eminence and posterior pituitary; they also reduced the concentrations of dihydroxyphenylacetic acid and the rate of synthesis of dopamine (DOPA accumulation after a decarboxylase inhibitor) in the same brain regions. On the other hand, the administration of deprenyl at doses that markedly inhibited type B monoamine oxidase did not alter the concentrations of dopamine, norepinephrine and dihydroxyphenylacetic acid or the rate of accumulation of DOPA in these brain regions. In addition, only clorgyline significantly lowered serum concentrations of prolactin. These results that type A monoamine oxidase catalyzes the intraneuronal deamination of dopamine within terminals of nigrostriatal, mesolimbic, tuberoinfundibular and tuberohypophyseal dopamine neurons.
氯吉兰（0.3 - 10毫克/千克，腹腔注射）可抑制大鼠纹状体和嗅结节匀浆中的A型单胺氧化酶（以5 - 羟色胺为底物），但不抑制B型单胺氧化酶（以苯乙胺为底物）；司来吉兰（0.3 - 3毫克/千克，腹腔注射）则抑制这些匀浆中的B型而非A型单胺氧化酶。相同剂量的氯吉兰可提高纹状体中多巴胺的浓度，以及嗅结节、正中隆起和垂体后叶中多巴胺和去甲肾上腺素的浓度；它们还降低了相同脑区中二羟基苯乙酸的浓度以及多巴胺的合成速率（脱羧酶抑制剂作用后多巴积累）。另一方面，给予能显著抑制B型单胺氧化酶的剂量的司来吉兰，并未改变这些脑区中多巴胺、去甲肾上腺素和二羟基苯乙酸的浓度或多巴的积累速率。此外，只有氯吉兰能显著降低血清催乳素浓度。这些结果表明，A型单胺氧化酶催化黑质纹状体、中脑边缘、结节漏斗和结节垂体多巴胺能神经元终末内多巴胺的神经元内脱氨基作用。
