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关于膜中脂肪酸转化的机制

On the mechanisms of fatty acid transformations in membranes.

作者信息

Gan-Elepano M, Aeberhard E, Mead J F

出版信息

Lipids. 1981 Nov;16(11):790-5. doi: 10.1007/BF02535030.

DOI:10.1007/BF02535030
PMID:6796797
Abstract

Concentrations of albumin in excess of 1% in the incubation mixture inhibited the elongation of added fatty acids and their incorporation into microsomal lipids whereas these reactions were not inhibited with endogenous microsomal membrane fatty acids. The results of these and other studies support the idea that such reactions of membrane lipid fatty acids with membrane-bound enzymes normally occur entirely within the membrane without release of free fatty acids to equilibrate with the fatty acid pool during the process.

摘要

孵育混合物中白蛋白浓度超过1%会抑制添加脂肪酸的延长及其掺入微粒体脂质,然而这些反应并未被内源性微粒体膜脂肪酸所抑制。这些研究以及其他研究的结果支持这样一种观点,即膜脂质脂肪酸与膜结合酶的此类反应通常完全在膜内发生,在此过程中不会释放游离脂肪酸与脂肪酸池达到平衡。

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引用本文的文献

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Neurochem Res. 1985 Oct;10(10):1343-53. doi: 10.1007/BF00964977.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Occurrence and properties of phospholipases A1 of plasma membranes prepared from neuronal- and glial-enriched fractions of the rabbit cerebral cortex.从兔大脑皮层富含神经元和胶质细胞的部分制备的质膜中磷脂酶A1的发生与特性
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Long chain base-acetyl coenzyme A acetyltransferase from the microsomes of Hansenula ciferri. II. Kinetic properties.
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Elongation of mitochondrial fatty acids during brain development.脑发育过程中线粒体脂肪酸的延长
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Rate equations and simulation curves for enzymatic reactions which utilize lipids as substrates. II. Effect of adsorption of the substrate or enzyme on the steady-state kinetics.以脂质为底物的酶促反应的速率方程和模拟曲线。II. 底物或酶的吸附对稳态动力学的影响。
Biochim Biophys Acta. 1977 Jul 20;488(1):13-24. doi: 10.1016/0005-2760(77)90118-7.
10
Rate equations and simulation curves for enzymatic reactions which utilize lipids as substrates. I. Interaction of enzymes with the monomers and micelles of soluble, amphiphilic lipids.以脂质为底物的酶促反应的速率方程和模拟曲线。I. 酶与可溶性两亲脂质单体和胶束的相互作用。
Biochim Biophys Acta. 1977 Jul 20;488(1):1-12. doi: 10.1016/0005-2760(77)90117-5.