Grignani G, Gamba G, Geroldi D, Pacchiarini L, Solerte B, Ferrari E, Ascari E
Thromb Haemost. 1981 Oct;46(3):648-51.
Some haemostatic parameters have been evaluated in a group of rigorously selected patients with maturity-onset diabetes mellitus without thromboembolic complications and in apparently normal subjects of the same age before and after the venous occlusion test (VOT). In basal conditions diabetics had higher levels of AT III as biological activity and higher fibrinolytic and antifibrinolytic activities than controls. After VOT, F VIII R:Ag increased significantly in both groups, more markedly in controls than in diabetics, while F VIII: C showed no modification. Also AT III R:Ag increased after the test, but such variation was significant only in diabetics; on the contrary, the biological activity of AT III was always significantly decreased after the test. After VOT there were also in both groups highly significant increases in the fibrinolytic and antifibrinolytic activities. Finally, HbA1c levels directly correlated with AT III as biological activity before VOT, but with no other parameter either before or after the test. These data suggest the existence in patients with diabetes mellitus without thromboembolic complications of an activated protective mechanism against intravascular clotting.
在一组经过严格挑选的无血栓栓塞并发症的成年型糖尿病患者以及一组年龄相仿的明显健康的对照者中，于静脉闭塞试验（VOT）前后评估了一些止血参数。在基础状态下，糖尿病患者的抗凝血酶III（AT III）生物活性水平、纤维蛋白溶解和抗纤维蛋白溶解活性均高于对照组。VOT后，两组的因子VIII相关抗原（F VIII R:Ag）均显著增加，对照组增加更为明显，而因子VIII促凝成分（F VIII:C）无变化。试验后抗凝血酶III抗原（AT III R:Ag）也增加，但这种变化仅在糖尿病患者中显著；相反，试验后抗凝血酶III的生物活性始终显著降低。VOT后，两组的纤维蛋白溶解和抗纤维蛋白溶解活性也均显著增加。最后，糖化血红蛋白（HbA1c）水平在VOT前与抗凝血酶III生物活性直接相关，但在试验前后与其他参数均无相关性。这些数据表明，在无血栓栓塞并发症的糖尿病患者中存在一种针对血管内凝血的激活保护机制。
