Ikenoue T, Martin C B, Murata Y, Ettinger B B, Lu P S
Am J Obstet Gynecol. 1981 Dec 1;141(7):797-806. doi: 10.1016/0002-9378(81)90707-9.
The fetal heart rate (FHR) response to acute nonacidemic hypoxemia and to acute respiratory acidosis was studied in unanesthetized pregnant monkeys by means of chronically implanted catheters and electrodes. Average FHR and short- and long-term FHR variability were analyzed separately. The FHR response to either hypoxemia or hypercapnia consisted of slowing and increased variability. The slowing was more consistent with hypercapnia than with hypoxemia. Long-term FHR variability increased with both test stresses. The increase in short-term FHR variability was much greater in response to hypoxemia than to hypercapnia. Both the FHR slowing and the increases in variability in response to the test stresses were reduced by prior administration of atropine to the fetus.
通过长期植入的导管和电极，在未麻醉的怀孕猴子身上研究了胎儿心率（FHR）对急性非酸血症性低氧血症和急性呼吸性酸中毒的反应。分别分析了平均FHR以及短期和长期FHR变异性。FHR对低氧血症或高碳酸血症的反应包括心率减慢和变异性增加。与低氧血症相比，心率减慢在高碳酸血症时更一致。两种试验应激下长期FHR变异性均增加。与高碳酸血症相比，低氧血症引起的短期FHR变异性增加要大得多。在给胎儿预先注射阿托品后，FHR减慢以及对试验应激反应的变异性增加均降低。
