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晚期癌症疼痛的测量

The measurement of pain in terminal carcinoma.

作者信息

Twycross R G

出版信息

J Int Med Res. 1976;4(2 Suppl):58-67.

PMID:67975
Abstract
  1. A method is described for comparing narcotic analgesics and adjuvants in patients with terminal cancer. 2. A randomized controlled trial of orally administered diamorphine and morphine is reported to illustrate the method. 3. It is concluded that there is no over-all clinical difference between diamorphine and morphine when administered by mouth every four hours at individually optimized doses in association with cocaine and a phenothiazine. 4. The validity, reliability and sensitivity of the method are discussed.
摘要
  1. 本文描述了一种在晚期癌症患者中比较麻醉性镇痛药和佐剂的方法。2. 据报道,一项关于口服二醋吗啡和吗啡的随机对照试验用以阐明该方法。3. 得出的结论是,当每四小时以个体化优化剂量口服二醋吗啡和吗啡,并联合使用可卡因和一种吩噻嗪时,二者在总体临床效果上并无差异。4. 讨论了该方法的有效性、可靠性和敏感性。

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The measurement of pain in terminal carcinoma.晚期癌症疼痛的测量
J Int Med Res. 1976;4(2 Suppl):58-67.
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Freedom from pain--a mirage or a possibility? Experience in attempts to change laws and practices in India.摆脱痛苦——是海市蜃楼还是一种可能?印度在试图改变法律与实践方面的经验。
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Efficacy and safety profile of a single dose of hydromorphone compared with morphine in older adults with acute, severe pain: a prospective, randomized, double-blind clinical trial.单剂量氢吗啡酮与吗啡用于急性重度疼痛老年患者的疗效和安全性比较:一项前瞻性、随机、双盲临床试验
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Efficacy and tolerability of intranasal fentanyl spray 50 to 200 microg for breakthrough pain in patients with cancer: a phase III, multinational, randomized, double-blind, placebo-controlled, crossover trial with a 10-month, open-label extension treatment period.鼻内注射50至200微克芬太尼喷雾剂对癌症患者爆发性疼痛的疗效和耐受性:一项III期、多国、随机、双盲、安慰剂对照、交叉试验,并有一个为期10个月的开放标签扩展治疗期。
Clin Ther. 2009 Jun;31(6):1177-91. doi: 10.1016/j.clinthera.2009.05.022.

引用本文的文献

1
Oral morphine for cancer pain.口服吗啡用于癌症疼痛。
Cochrane Database Syst Rev. 2016 Apr 22;4(4):CD003868. doi: 10.1002/14651858.CD003868.pub4.
2
Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain.吗啡、芬太尼、羟考酮或可待因用于治疗癌痛时对患者意识、食欲和口渴的影响。
Cochrane Database Syst Rev. 2014 May 29;2014(5):CD011056. doi: 10.1002/14651858.CD011056.pub2.