Beraud M, Gaillard D, Pipy B, Derache R
Cancer Lett. 1981 Nov;14(2):169-74. doi: 10.1016/0304-3835(81)90127-0.
After a single intragastric administration of 14C-labelled carcinogenic nitrosocarbaryl, a nitrosated pesticide, the distribution of radioactivity was investigated in the blood and a number of organs in male rats. The animals received 0.25 mg/kg of labelled nitrosamine and were killed following administration at timed intervals between 0.5 h and 24 h. Our results show that the greatest amount of the 14CH3--group was associated with the forestomach, tumor-susceptible tissue; the level of radioactivity is noteworthy but less important in the glandular stomach. There are also sites of radioactivity accumulation mainly in the liver. Moreover, [14C]nitrosocarbaryl was revealed in the blood suggesting that nitrosamine itself rapidly (0.5 h) crosses the intestinal barrier and in a significant quantity (13%). These facts constitute a potential carcinogenic risk.
在给雄性大鼠一次性胃内给予14C标记的致癌性亚硝基卡巴胂（一种亚硝化的农药）后，对血液和多个器官中的放射性分布进行了研究。这些动物接受了0.25毫克/千克的标记亚硝胺，并在给药后0.5小时至24小时的不同时间间隔处死。我们的结果表明，14CH3-基团的最大量与前胃（肿瘤易感组织）相关；放射性水平值得注意，但在腺胃中不太重要。放射性积累的部位也主要在肝脏。此外，在血液中检测到了[14C]亚硝基卡巴胂，这表明亚硝胺本身能迅速（0.5小时）穿过肠道屏障，且数量可观（13%）。这些事实构成了潜在的致癌风险。
