Chang Y C, Falkson G, Tormey D C, Crowley J
Cancer Clin Trials. 1981 Winter;4(4):377-80.
A four-drug combination of intermittent high-dose cyclophosphamide with 5-fluorouracil, hexamethylmelamine, and prednisone was given to 19 patients with advanced breast cancer. Objective response was documented in 7 of 18 evaluable patients. The median duration of response was 99 days. Response was observed in 6/7 patients without visceral disease and 1/11 patients with visceral disease. Toxicity was acceptable and no life-threatening toxicity was observed. Three patients have received the four-drug combination for more than 1 year without serious side effects. This regimen may serve as an alternative treatment for patients without visceral metastasis who have failed to respond to other combination chemotherapy regimens.
对19例晚期乳腺癌患者给予间歇性大剂量环磷酰胺联合5-氟尿嘧啶、六甲蜜胺和泼尼松的四联疗法。18例可评估患者中有7例记录到客观缓解。缓解的中位持续时间为99天。在无内脏疾病的7例患者中有6例出现缓解，在内脏疾病患者的11例中有1例出现缓解。毒性是可接受的，未观察到危及生命的毒性。3例患者接受四联疗法超过1年且无严重副作用。对于对其他联合化疗方案无反应的无内脏转移患者，该方案可作为一种替代治疗方法。
