Pepine C J, Feldman R L, Conti C R
Circulation. 1982 Feb;65(2):411-4. doi: 10.1161/01.cir.65.2.411.
Coronary artery spasm usually responds to sublingual nitroglycerin. This report describes four patients with variant angina and one patient with rest angina who had coronary spasm that was refractory to sublingual or i.v. nitroglycerin. In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine. In each case, 25-100 micrograms of intracoronary nitroglycerin promptly (30-45 seconds) resulted in reopacification of the vessel involved in spasm and resolution of evidence for ischemia. Thus, intracoronary nitroglycerin can reverse coronary artery spasm that does not respond to systemic nitroglycerin administration.
冠状动脉痉挛通常对舌下含服硝酸甘油有反应。本报告描述了4例变异型心绞痛患者和1例静息性心绞痛患者，他们的冠状动脉痉挛对舌下或静脉注射硝酸甘油均无反应。4例患者痉挛自发发生，1例患者在注射0.05 mg麦角新碱后出现痉挛。在每种情况下，冠状动脉内注射25 - 100微克硝酸甘油可迅速（30 - 45秒）使发生痉挛的血管重新显影，并消除缺血证据。因此，冠状动脉内注射硝酸甘油可逆转对全身应用硝酸甘油无反应的冠状动脉痉挛。
