Jaffiol C, Baldet L, Missonne C L, Papachristou C
Clin Endocrinol (Oxf). 1981 Oct;15(4):417-21. doi: 10.1111/j.1365-2265.1981.tb00683.x.
A major reduction in T3 turnover has been demonstrated previously in clinically hypothyroid patients. We have used non-compartmental (NC) and monocompartmental (MC) analysis to study ten patients with Graves' disease who, following treatment with radioactive iodine (RAI), are now clinically euthyroid but who showed hyper-responsiveness to TRH although serum T3 and T4 concentrations are within the normal range. T3 production rate (PR), metabolic clearance rate (MRC) and fractional-turnover (K) were all significantly reduced in patients compared with seven controls (P less than 0.01). T3, MCR and PR were consistently higher, and T3 K lower, when calculated by MC, than values calculated by NC analysis. The difference in T3 production rates between patients (mean 16.6 nmol/day) and controls (mean 38.9 nmol/day) raises the question of replacement therapy in patients who are apparently euthyroid but TRH hyper-responsive.
先前已证实在临床甲状腺功能减退患者中T3周转率大幅降低。我们采用非房室（NC）和单房室（MC）分析法研究了10例格雷夫斯病患者，这些患者经放射性碘（RAI）治疗后目前临床甲状腺功能正常，但尽管血清T3和T4浓度在正常范围内，对促甲状腺激素释放激素（TRH）仍表现出高反应性。与7名对照者相比，患者的T3生成率（PR）、代谢清除率（MRC）和分数周转率（K）均显著降低（P<0.01）。通过MC计算时，T3、MCR和PR始终较高，而T3 K低于通过NC分析计算的值。患者（平均16.6 nmol/天）和对照者（平均38.9 nmol/天）之间T3生成率的差异引发了对于表面上甲状腺功能正常但对TRH高反应性患者替代治疗的问题。
