Ranta R, Ylipaavalniemi P, Altonen M, Calonius P E
Int J Oral Surg. 1981 Apr;10(2):122-7. doi: 10.1016/s0300-9785(81)80021-x.
The healing of bone defect in eight adult rabbits was studied. The age range of animals was 5-23 months. The bone defects were made symmetrically in the inferior surface of the mandibles. At the defect site the root surface of continuously erupting mandibular incisors was exposed. On the left side, the bone defect was covered with a local periosteal flap (control side) and on the right side the defect was covered with a free periosteal graft from the tibia (test side). The healing of bone defects and the amount of new bone were studied. The quality of the bone formed was investigated histologically. The findings of this investigation led to the following conclusions: (1) The bone defects healed on both sides. The amount of bone on the control side was identical to that in the anatomical region. On the test side the amount of bone formed was in seven cases two to threefold that formed on the control side. (2) The histological study proved that the bone formed was lamellar bone, being identical on both the control and the test side. (3) The ages of the animals or the length of follow-up time did not affect the amount of new bone, the healing of the defect or the quality of new bone. (4) The eruption of the incisors was symmetrical. In this study the free periosteal graft from the tibia led to better bone formation than the local periosteal flap in the induced bone defects of the tooth-bearing region in the mandible of the adult rabbit.
对8只成年兔子的骨缺损愈合情况进行了研究。动物的年龄范围为5 - 23个月。在下颌骨下表面对称制造骨缺损。在缺损部位，持续萌出的下颌切牙的牙根表面暴露。左侧，骨缺损用局部骨膜瓣覆盖（对照侧），右侧缺损用来自胫骨的游离骨膜移植片覆盖（试验侧）。研究了骨缺损的愈合情况和新骨量。对形成的骨的质量进行了组织学研究。本研究的结果得出以下结论：（1）两侧的骨缺损均愈合。对照侧的骨量与解剖区域的骨量相同。在试验侧，7例中形成的骨量是对照侧的两到三倍。（2）组织学研究证明形成的骨是板层骨，对照侧和试验侧相同。（3）动物的年龄或随访时间的长短不影响新骨量、缺损的愈合或新骨的质量。（4）切牙的萌出是对称的。在本研究中，来自胫骨的游离骨膜移植片在成年兔子下颌骨含牙区域的诱导骨缺损中比局部骨膜瓣导致更好的骨形成。
