Carter D A, Pennington J M, Whitehead S A
J Reprod Fertil. 1982 Jan;64(1):191-7. doi: 10.1530/jrf.0.0640191.
Domperidone at a dose of 4 mg/kg significantly raised circulating prolactin levels in male and female rats although this increase was approximately 4-fold higher in females compared with males. No effect on LH secretion was observed. This LH and prolactin responses to Gn-RH and TRH respectively were investigated with isolated perfused pituitary glands obtained from domperidone-pretreated animals. For females, the basal release of prolactin was raised by domperidone pretreatment and the responsiveness of the pituitary to Gn-RH was markedly attenuated. When domperidone was added to the perfusing media, high concentrations (100 microgram/ml) reduced both the basal and TRH-stimulated prolactin secretion from pituitaries of untreated male and female rats although lower doses (1 microgram/ml and 10 ng/ml) were ineffective in altering prolactin release. The pituitary LH responses to Gn-RH were similarly reduced by the presence of 100 microgram domperidone/ml in the medium.
剂量为4毫克/千克的多潘立酮显著提高了雄性和雌性大鼠的循环催乳素水平，不过与雄性相比，雌性大鼠的这种升高幅度约高4倍。未观察到对促黄体生成素（LH）分泌有影响。利用从经多潘立酮预处理的动物身上获取的离体灌注垂体，分别研究了LH和催乳素对促性腺激素释放激素（Gn-RH）和促甲状腺激素释放激素（TRH）的反应。对于雌性大鼠，多潘立酮预处理提高了催乳素的基础释放量，且垂体对Gn-RH的反应性明显减弱。当将多潘立酮添加到灌注培养基中时，高浓度（100微克/毫升）降低了未处理的雄性和雌性大鼠垂体的基础催乳素分泌以及TRH刺激的催乳素分泌，不过较低剂量（1微克/毫升和10纳克/毫升）在改变催乳素释放方面无效。培养基中存在100微克/毫升多潘立酮时，垂体对Gn-RH的LH反应同样降低。
