Dudley S D
Neurosci Biobehav Rev. 1981 Winter;5(4):421-35. doi: 10.1016/0149-7634(81)90013-0.
The physiological response to systemic estrogens changes dramatically during the period from birth to puberty. With the onset of puberty, the rat reaches a critical developmental plateau with regard to endocrinological responsiveness to estradiol. Since the appearance of the pubertal response pattern appears to be less a consequence of some intrinsic "trigger' than the natural continuation of a developmental sequence that begins prenatally, its ontogeny should be examined in a broad context that will take account of the impact of each of the dynamic components influencing the interactions between estradiol and the central nervous system on the functional development of the organism as a whole. The prepubertal ontogeny of endocrinological responsiveness to estradiol in the central nervous system of the female rat is examined in the context of several of the important factors that are known to influence the functional development of the hypothalamo-pituitary-gonadal circuit:the rapidly changing hormonal environment of the morphologically and physiologically immature juvenile rat, the shifting predominance of alphafetoprotein and "adult" estradiol-binding protein, sexual differentiation of the neural substrate, and the development of mature pituitary-gonadal feedback mechanisms. The availability of ever more sensitive techniques for the measurement of the actions of estradiol in the central nervous system of the immature organism has necessitated a re-evaluation of existing data. This, in turn, suggests that new approaches should be applied to the examination of problems related to the development of reproductive maturity of the central nervous system.
从出生到青春期，机体对全身性雌激素的生理反应会发生巨大变化。随着青春期的开始，大鼠在对雌二醇的内分泌反应方面达到了一个关键的发育平台期。由于青春期反应模式的出现似乎并非某种内在“触发因素”的结果，而是始于产前的发育序列的自然延续，因此其个体发育应在一个广泛的背景下进行研究，该背景应考虑到影响雌二醇与中枢神经系统之间相互作用的每个动态组成部分对整个机体功能发育的影响。本文在已知影响下丘脑 - 垂体 - 性腺轴功能发育的几个重要因素的背景下，研究了雌性大鼠中枢神经系统对雌二醇内分泌反应的青春期前个体发育：形态和生理上未成熟的幼鼠快速变化的激素环境、甲胎蛋白和“成年”雌二醇结合蛋白优势的转变、神经基质的性别分化以及成熟垂体 - 性腺反馈机制的发育。用于测量未成熟机体中枢神经系统中雌二醇作用的更灵敏技术的出现，使得有必要对现有数据进行重新评估。这反过来又表明，应该采用新的方法来研究与中枢神经系统生殖成熟发育相关的问题。
