Ishii N, Tsuda M, Saheki T, Suzuki K, Katsunuma T
Tokai J Exp Clin Med. 1981 Oct;6(4):333-41.
Properties of argininosuccinate synthetases (ASS), including immunological properties and heat stability, from young and old rats were quite similar. However the degradation rates of ASS from young and old rats were found to be different as shown in the experiment using the double labeling technique. Three forms of this enzyme from young and old rat livers were separated by DEAE-Sephadex A-50 column chromatography, and they were called ASS 1, 2 and 3 in order of elution. The degradation rate of ASS 1 from young and old rat livers was very similar, but the rate of degradation of ASS 2 form old rat livers was greater than that from young rat livers.
来自年轻和老年大鼠的精氨琥珀酸合成酶（ASS）的特性，包括免疫学特性和热稳定性，非常相似。然而，如使用双标记技术的实验所示，发现年轻和老年大鼠的ASS降解率有所不同。通过DEAE-葡聚糖A-50柱色谱法分离了来自年轻和老年大鼠肝脏的三种形式的这种酶，按照洗脱顺序它们被称为ASS 1、2和3。来自年轻和老年大鼠肝脏的ASS 1的降解率非常相似，但老年大鼠肝脏中ASS 2的降解率大于年轻大鼠肝脏中的降解率。
