Kerr-Wilson R H, MacKenzie L, Fraser H M
Contraception. 1981 Dec;24(6):647-55. doi: 10.1016/0010-7824(81)90016-0.
Eight stumptailed macaques were injected daily with 5 or 20 micrograms D-Ser(But)6des Gly luteinizing hormone releasing hormone ethylamide (LHRH agonist) for approximately one year in order to prevent ovulation. On the last day of treatment (7 monkeys) or during the mid-luteal phase of the first cycle after treatment (1 monkey), a laparotomy was performed. Uterine size was slightly smaller (P less than 0.01) than in controls with normal cycles (n = 6). A full thickness wedge of anterior uterine wall was excised and examined histologically. Five of the agonist-treated monkeys had endometrium consistent with an atropic or resting proliferative pattern, but in 2 the appearance varied from early proliferative to marked secretory. All appeared entirely benign. The remaining animal studied in the luteal phase after stopping treatment exhibited a normal secretory endometrium. Ovaries from 2 of the LHRH agonist-treated animals were also studied histologically and found to consist of follicles at various stages of maturation. The occurrence of endometrial activity in 2 of the 8 LHRH agonist-treated monkeys stresses the need for careful endometrial assessment during clinical trials involving repeated administration of LHRH agonists in women.
为了防止排卵，对8只短尾猕猴每天注射5或20微克的D-丝氨酸（叔丁基）6去甘氨酸促黄体生成素释放激素乙酰胺（LHRH激动剂），持续约一年时间。在治疗的最后一天（7只猴子）或治疗后的第一个周期的黄体中期（1只猴子），进行了剖腹手术。子宫大小比正常周期的对照组（n = 6）略小（P < 0.01）。切除子宫前壁全层楔形组织并进行组织学检查。接受激动剂治疗的5只猴子的子宫内膜表现为萎缩或静止增殖模式，但有2只的外观从早期增殖到明显分泌不等。所有表现均完全为良性。在停止治疗后的黄体期研究的另一只动物表现出正常的分泌期子宫内膜。对2只接受LHRH激动剂治疗的动物的卵巢也进行了组织学研究，发现由处于不同成熟阶段的卵泡组成。在8只接受LHRH激动剂治疗的猴子中有2只出现子宫内膜活动，这突出了在涉及女性反复施用LHRH激动剂的临床试验期间仔细评估子宫内膜的必要性。
