胎鼠下丘脑 - 垂体 - 促性腺激素活性的发育
Development of the hypothalamic-hypophysial-gonadotrophic activities in fetal rats.
作者信息
Daikoku S, Adachi T, Kawano H, Wakabayashi K
出版信息
Experientia. 1981 Dec 15;37(12):1346-7. doi: 10.1007/BF01948403.
Pituitary responsiveness to LHRH and anti-LHRH serum was investigated in fetal rats aged 18.5-22.5 days. Synthetic LHRH injection in utero into fetuses brought about a remarkable depletion of pituitary-LH with a corresponding increase of serum-LH on day 18.5. On the contrary, anit-LHRH serum administration to day-20.5 fetuses caused a significant augmentation of pituitary-LH 1 day later. These data indicate that LH-gonadotrophs respond to LHRH even on day 18.5, and that endogenous LHRH begins to affect LH gonadotrophs on day 20.5.
研究了18.5 - 22.5日龄胎鼠垂体对促黄体生成素释放激素（LHRH）和抗LHRH血清的反应。在子宫内给18.5日龄胎儿注射合成LHRH，可导致垂体促黄体生成素（LH）显著减少，同时血清LH相应增加。相反，给20.5日龄胎儿注射抗LHRH血清，1天后垂体LH显著增加。这些数据表明，即使在18.5日龄时，促性腺激素细胞也对LHRH有反应，并且内源性LHRH在20.5日龄时开始影响促性腺激素细胞。
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