Radziuk J
Fed Proc. 1982 Jan;41(1):110-6.
The role of hepatic glycogen is central in the short-term storage and supply of glucose. In the studies described, both glucose and its precursors are labeled and their incorporation into hepatic glycogen is measured during absorption of an oral glucose load in humans. The measurements are accomplished using tracer-determined non-steady-state turnover techniques. Mobilization of newly formed glycogen is achieved by glucagon infusions. After ingestion of a 100-g glucose load in normal fasting (12 h) man, no more than 10 g of the glucose taken up by the liver is converted directly into glycogen. On the other hand, by measuring the uptake of 14C from 14CO2 into glycogen and correcting for Krebs cycle exchange of label, at least an additional 15 g of the glycogen formed can simultaneously be accounted for by new synthesis of glycogen from glucogenic precursors.
肝糖原在葡萄糖的短期储存和供应中起着核心作用。在所描述的研究中，葡萄糖及其前体均被标记，并且在人体口服葡萄糖负荷吸收期间测量它们掺入肝糖原的情况。这些测量是使用示踪剂测定的非稳态周转技术完成的。通过输注胰高血糖素来实现新形成糖原的动员。在正常禁食（12小时）的男性摄入100克葡萄糖负荷后，肝脏摄取的葡萄糖中直接转化为糖原的不超过10克。另一方面，通过测量14C从14CO2掺入糖原并校正标记的三羧酸循环交换，由生糖前体新合成糖原可同时至少再解释所形成糖原的15克。
