Pesenti A, Kolobow T, Buckhold D K, Pierce J E, Huang H, Chen V
Intensive Care Med. 1982 Jan;8(1):11-7. doi: 10.1007/BF01686848.
Hyaline membrane disease is found only in lungs where pulmonary ventilation has been established, i.e. after birth. We delivered eleven fetal lambs of a gestational age of 128-130 days but instead kept their lungs in total apnea and inflated to constant pressure, while removing all metabolically produced carbon dioxide with an extracorporeal membrane lung. Oxygen was provided by the membrane lung, and by apneic oxygenation through the natural lungs. Hence, arterial blood gases remained always normal, without any pulmonary ventilation. After 6-66 h the lungs had sufficiently cleared to allow normal mechanical pulmonary ventilation in 10 our of 11 lambs so treated. In a control group treated with mechanical ventilation alone, five of seven lambs died within the first 24 h of severe hyaline membrane disease.
透明膜病仅见于已建立肺通气的肺，即出生后。我们娩出了11只胎龄为128 - 130天的胎羊，但使它们的肺完全处于无呼吸状态并维持恒定压力充气，同时用体外膜肺去除所有代谢产生的二氧化碳。氧气由膜肺提供，并通过自然肺进行无呼吸氧合。因此，在没有任何肺通气的情况下，动脉血气始终保持正常。6 - 66小时后，11只接受该治疗的羔羊中有10只的肺已充分清理，从而能够进行正常的机械性肺通气。在仅接受机械通气治疗的对照组中，7只羔羊中有5只在严重透明膜病的最初24小时内死亡。
