Enyedi P, Spät A, Antoni F A
J Endocrinol. 1981 Dec;91(3):427-37. doi: 10.1677/joe.0.0910427.
The role of prostaglandins in the control of aldosterone production was studied in isolated rat glomerulosa cells. Exogenous prostaglandin E2 in concentrations above 10(-9) mol/l increased the production rate of aldosterone; this effect was attenuated by the competitive antagonist, 7-oxa-13-prostynoic acid. Prostaglandin F2 alpha (10(-9)--10(-5) mol/l) failed to influence the production rate of aldosterone. The aldosterone-stimulating effect of the prostaglandin precursor, arachidonic acid (5 x 10(-4) mol/l), could not be blocked by inhibitors of prostaglandin synthesis. Basal production rate of aldosterone was not significantly influenced by non-steroidal anti-inflammatory drugs. Glomerulosa cells were stimulated by angiotensin II; this effect was not potentiated by arachidonic acid and was reduced only slightly by indomethacin. The cells were also stimulated by corticotrophin and potassium ions. The effect of these substances was not potentiated by arachidonic acid and was not inhibited by non-steroidal anti-inflammatory drugs. These results do not confirm the presumption that intra-adrenal prostaglandins play an essential role in the control of aldosterone secretion. Some effects of arachidonic acid and its antagonist, eicosatetraynoic acid, on aldosterone production are considered to be independent of changes in prostaglandin synthesis.
在分离的大鼠肾小球旁细胞中研究了前列腺素在醛固酮分泌调控中的作用。浓度高于10(-9)mol/L的外源性前列腺素E2可提高醛固酮的分泌率；该作用被竞争性拮抗剂7-氧杂-13-前列腺炔酸减弱。前列腺素F2α（10(-9)--10(-5)mol/L）未能影响醛固酮的分泌率。前列腺素前体花生四烯酸（5×10(-4)mol/L）刺激醛固酮分泌的作用不能被前列腺素合成抑制剂阻断。非甾体抗炎药对醛固酮的基础分泌率无显著影响。肾小球旁细胞可被血管紧张素II刺激；该作用未被花生四烯酸增强，仅被吲哚美辛轻微减弱。这些细胞也可被促肾上腺皮质激素和钾离子刺激。这些物质的作用未被花生四烯酸增强，也未被非甾体抗炎药抑制。这些结果并未证实肾上腺内前列腺素在醛固酮分泌调控中起关键作用这一推测。花生四烯酸及其拮抗剂二十碳四炔酸对醛固酮分泌的某些作用被认为与前列腺素合成的变化无关。
