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人滋养层细胞在体外是对免疫影响具有适应性的组织吗?

Is the human trophoblast in vitro an adaptive tissue for immunological influences?

作者信息

Kolesnikov S I, Trunova L A, Ignatovich N V, Paraskun V G

出版信息

Acta Biol Acad Sci Hung. 1981;32(2):147-56.

PMID:6800169
Abstract

The role of the extra-embryonic organs (e.g. placenta) in the feto-maternal immunological interactions is not clear. Trophoblast cells of human placenta were studied in vitro in relation to their adaptive capacities under the immunological influence of allogeneic leucocytes of pregnant women. It was shown that after an 18-h interaction some trophoblastic cells were still viable, they were rich in glycoproteins and RNA, and elicited a prominent activity of some enzymes. Mitosis was often seen. The authors suppose that the trophoblast is highly adaptable to some immunological influences in vitro.

摘要

胚外器官(如胎盘)在母胎免疫相互作用中的作用尚不清楚。研究了人胎盘滋养层细胞在孕妇同种异体白细胞免疫影响下的体外适应能力。结果表明,经过18小时的相互作用后,一些滋养层细胞仍然存活,它们富含糖蛋白和RNA,并引发了一些酶的显著活性。经常可见有丝分裂。作者认为,滋养层在体外对某些免疫影响具有高度适应性。

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