多巴胺自身受体控制黑质中多巴胺合成的证据。

Evidence for dopamine autoreceptors controlling dopamine synthesis in the substantia nigra.

作者信息

Argiolas A, Melis M R, Fadda F, Gessa G L

出版信息

Brain Res. 1982 Feb 18;234(1):177-81. doi: 10.1016/0006-8993(82)90484-x.

Abstract

The effect of apomorphine and haloperidol on DOPA accumulation after inhibition of DOPA decarboxylase activity with NSD 1015 was compared in the substantia nigra (SN) and caudate nucleus (CN) of normal rats and rats deprived of nigral afferences from the striatum by means of intrastriatal kainic acid. In normal rats apomorphine decreased DOPA accumulation to the same extent in both the SN and CN. However, haloperidol produced a more pronounced increase in DOPA accumulation in the CN than in the SN. The effect of both drugs still persisted in the SN and CN after destruction of the neuronal strionigral feedback loop with kainic acid. The results provide evidence for the existence of nigral dopamine autoreceptors controlling dopamine synthesis in the SN.

摘要

比较了阿扑吗啡和氟哌啶醇对正常大鼠以及通过纹状体内注射 kainic 酸使纹状体黑质传入纤维缺失的大鼠，在用 NSD 1015 抑制多巴脱羧酶活性后黑质（SN）和尾状核（CN）中多巴积累的影响。在正常大鼠中，阿扑吗啡在 SN 和 CN 中使多巴积累降低的程度相同。然而，氟哌啶醇在 CN 中使多巴积累增加的程度比在 SN 中更明显。在用 kainic 酸破坏神经元纹状体黑质反馈回路后，两种药物在 SN 和 CN 中的作用仍然存在。这些结果为存在控制 SN 中多巴胺合成的黑质多巴胺自身受体提供了证据。