甲状腺功能亢进症Graves病抗甲状腺治疗后发生的自发性甲状腺功能减退症。

Spontaneous hypothyroidism after antithyroid treatment of hyperthyroid Graves' disease.

作者信息

Lamberg B A, Salmi J, Wägar G, Mäkinen T

出版信息

J Endocrinol Invest. 1981 Oct-Dec;4(4):399-402. doi: 10.1007/BF03348302.

Abstract

Out of 54 patients with hyperthyroid Graves' disease 35 remained euthyroid after treatment with antithyroid agents and have been continuously followed from 1 to 9 yr (4.85 +/- 2.55 yr, mean +/- SD). In 4 patients an exaggerated TSH response to TRH developed from 30 to 111 months after interrupting the treatment and one of them became hypothyroid 50 months (5.0 yr) thereafter. The annual incidence of subclinical hypothyroidism (exaggerated response to TRH) as calculated from the total number of observation yr was 2.5% and that of overt hypothyroidism was 0.6%. These figures are similar to those reported recently in 2 retrospective studies.

摘要

在54例甲状腺功能亢进的格雷夫斯病患者中，35例在接受抗甲状腺药物治疗后甲状腺功能恢复正常，并已持续随访1至9年（平均4.85±2.55年，均值±标准差）。4例患者在中断治疗后30至111个月出现对促甲状腺激素释放激素（TRH）的促甲状腺激素（TSH）反应过度，其中1例在50个月（5.0年）后发生甲状腺功能减退。根据总观察年限计算，亚临床甲状腺功能减退（对TRH反应过度）的年发病率为2.5%，显性甲状腺功能减退的年发病率为0.6%。这些数字与最近两项回顾性研究报告的数字相似。