Berman J W, Basch R S
J Immunol. 1982 Apr;128(4):1718-22.
The SC-1 antigen, identified by thymus-absorbed rabbit anti-mouse brain antiserum, is present on multipotential stem cells. Its presence on cells of the T lineage has been examined by immunofluorescence, and we have demonstrated that it is also a marker for thymic development. Although it is present on the majority of fetal and neonatal thymocytes, its expression declines rapidly and, as early as 1 mo after birth, adult levels are reached. In normal animals, these do not change during adult life, even in mice destined to develop a T cell leukemia. SC-1 does reappear transiently on cells in the regenerating thymus of sublethally irradiated mice. Although the antigen is not associated with preleukemic changes in the thymus, it is expressed on some cells of all spontaneous T lymphomas, and it is uniformly present on tissue culture lines of T cell lymphomas.
由胸腺吸收的兔抗鼠脑抗血清鉴定出的SC-1抗原存在于多能干细胞上。通过免疫荧光检测了它在T系细胞上的存在情况，我们已经证明它也是胸腺发育的一个标志物。虽然它存在于大多数胎儿和新生胸腺细胞上，但其表达迅速下降，早在出生后1个月就达到了成年水平。在正常动物中，这些水平在成年期不会改变，即使是注定要发生T细胞白血病的小鼠也是如此。SC-1确实会在亚致死剂量照射小鼠的再生胸腺中的细胞上短暂重新出现。虽然该抗原与胸腺中的白血病前期变化无关，但它在所有自发性T淋巴瘤的一些细胞上表达，并且在T细胞淋巴瘤的组织培养系中均有表达。
