Nicolatou O E
J Oral Pathol. 1981 Oct;10(5):311-21. doi: 10.1111/j.1600-0714.1981.tb01283.x.
The effects of fractionated X-irradiation following isoproterenol (IPN) administration on rat parotid gland were studied 4, 8, and 12 weeks post-irradiation. Degenerative and necrotic changes of the acinar cells were observed at all three time intervals as a result of the radiation. These changes were more obvious 4 and 8 weeks post-irradiation and isoproterenol administration. The necrotic acinar cells were replaced by fibrous connective tissue, especially conspicuous at 12 weeks. Reparative changes were observed along with the degenerative and regressive phenomena of the gland. Enlarged acinar cells and nuclei were observed as early as 4 weeks post-irradiation. This change was focally distributed at the 4-week interval but more widespread 8 and 12 weeks post-irradiation. Mitochondrial hyperplasia with alteration of mitochondrial cristae was observed 12 weeks post-irradiation. Proliferation of cells of ductal origin and nodular proliferation of ducts were observed 12 weeks after isoproterenol administration plus X-irradiation. These proliferative phenomena may represent an early stage of tumor formation resulting from the combined effect of isoproterenol and X-irradiation on rat parotid gland.
研究了异丙肾上腺素（IPN）给药后分次X线照射对大鼠腮腺的影响，观察时间为照射后4周、8周和12周。由于辐射，在所有三个时间间隔均观察到腺泡细胞的变性和坏死变化。这些变化在照射后4周和8周以及给予异丙肾上腺素后更为明显。坏死的腺泡细胞被纤维结缔组织取代，在12周时尤为明显。在腺体发生变性和退行性现象的同时，观察到了修复性变化。早在照射后4周就观察到腺泡细胞和细胞核增大。这种变化在4周时呈局灶性分布，但在照射后8周和12周分布更广泛。照射后12周观察到线粒体增生及线粒体嵴改变。在给予异丙肾上腺素加X线照射12周后，观察到导管来源细胞的增殖和导管的结节状增殖。这些增殖现象可能代表异丙肾上腺素和X线照射联合作用于大鼠腮腺后肿瘤形成的早期阶段。
