Stanton T L, Winokur A, Beckman A L
Regul Pept. 1982 Feb;3(2):135-44. doi: 10.1016/0167-0115(82)90090-8.
We have measured the endogenous TRH concentration in the pineal and 9 brain regions of a seasonal hibernator, the golden-mantled ground squirrel, during euthermia and hibernation in order to investigate the possibility that changes in TRH concentration might occur in association with naturally-occurring changes in CNS-mediated physiological and behavioral processes. Regional TRH content was assessed by radioimmunoassay in adult animals that were killed during euthermia in the mid-portion of each season and during hibernation in mid-winter. No significant changes in TRH concentration related to season or to hibernation versus euthermic state were noted in the hippocampus, brainstem, or cerebellum. In the olfactory bulb, preoptic area, and pineal, seasonal variation within euthermic groups was evident. During hibernation, statistically significant decreases in TRH content occurred in the forebrain, olfactory bulb, hypothalamus, septum, preoptic area, and midbrain. Significant fluctuations during hibernation were also observed in the pineal. In this structure, TRH concentration varied in relation to the phase of the hibernation bout. TRH content in the last quarter of the bout was three times greater when compared to values observed in the first quarter of the bout. These results suggest that TRH may be involved in the control processes attributed to these regions and support a role for TRH in the neural control of hibernation.
我们测定了季节性冬眠动物金黄地鼠在正常体温和冬眠状态下松果体及9个脑区的内源性促甲状腺激素释放激素（TRH）浓度，以研究TRH浓度变化是否可能与中枢神经系统介导的生理和行为过程的自然变化相关。通过放射免疫分析法评估成年动物的区域TRH含量，这些动物在每个季节中期的正常体温期以及冬中的冬眠期被处死。在海马体、脑干或小脑中，未发现与季节或冬眠与正常体温状态相关的TRH浓度有显著变化。在嗅球、视前区和松果体中，正常体温组内存在明显的季节性变化。在冬眠期间，前脑、嗅球、下丘脑、隔区、视前区和中脑的TRH含量出现了统计学上的显著下降。松果体在冬眠期间也观察到显著波动。在这个结构中，TRH浓度随冬眠周期的阶段而变化。与冬眠周期第一季度观察到的值相比，最后一个季度的TRH含量大三倍。这些结果表明，TRH可能参与了归因于这些区域的控制过程，并支持TRH在冬眠的神经控制中发挥作用。
