长期服用吲哚美辛后发生的再生障碍性贫血。
Aplastic anemia after prolonged ingestion of indomethacin.
作者信息
Kornberg A, Rachmilewitz E A
出版信息
Acta Haematol. 1982;67(2):136-8. doi: 10.1159/000207041.
PMID:6801896
Abstract
Two rare cases of aplastic anemia after prolonged ingestion of indomethacin are described. One patient recovered spontaneously within several weeks following discontinuation of the drug while the second one died. The aplastic anemia may be related to the inhibitory effect of indomethacin on prostaglandins and cyclic nucleotides which have a regulatory role in erythropoiesis and myelopoiesis.
摘要
本文描述了两例长期服用吲哚美辛后发生再生障碍性贫血的罕见病例。一例患者在停药后数周内自发康复，而另一例患者死亡。再生障碍性贫血可能与吲哚美辛对前列腺素和环核苷酸的抑制作用有关，而前列腺素和环核苷酸在红细胞生成和粒细胞生成中起调节作用。
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