与冷球蛋白血症和冷球蛋白尿相关的IgD浆细胞白血病。新型冷球蛋白和细胞质原纤维。

IgD-plasma cell leukemia associated with pyroglobulinemia and pyroglobulinuria. New types of pyroglobulin and cytoplasmic fibrils.

作者信息

Tsuda H, Kishimoto S

出版信息

Acta Haematol. 1982;67(2):80-6. doi: 10.1159/000207031.

DOI:10.1159/000207031

PMID:6801901

Abstract

New pyroglobulin variants were found in a patient with a typical plasma cell leukemia. One was found in the urine and proved to be a variant of Bence-Jones' protein with a molecular weight of approximately 68,000. The other was found in the serum and appears to be the myeloma protein of IgD. Furthermore, an ultrastructural study disclosed myeloma cells in both peripheral blood and bone marrow to have cytoplasmic fibrils which might be unique for plasma cell leukemia.

摘要

在一名典型的浆细胞白血病患者中发现了新的热球蛋白变体。其中一种在尿液中发现，经证实是分子量约为68,000的本-周蛋白变体。另一种在血清中发现，似乎是IgD型骨髓瘤蛋白。此外，超微结构研究显示外周血和骨髓中的骨髓瘤细胞都有细胞质纤维，这可能是浆细胞白血病所特有的。