克氏锥虫感染无症状个体对组织抗原的白细胞迁移抑制反应。
Leucocyte migration inhibition response to tissue antigens in asymptomatic individuals infected with Trypanosoma cruzi.
作者信息
Peralta J M, Gill K, Cordeiro Lima M F, Coura J R
出版信息
Clin Exp Immunol. 1981 Sep;45(3):621-6.
The direct leucocyte migration inhibition test was used to study 31 asymptomatic humans chronically infected with Trypanosoma cruzi and 23 normal uninfected controls. The antigenic preparations used were made from mouse and guinea-pig heart, skeletal muscle, kidney, liver and brain. Positive responses were found in the parasite-infected individuals to kidney, liver and brain antigen but not to antigen prepared from heart of skeletal muscle tissue. No correlation was found between T. cruzi antibody titres and migration index values to these various antigens. On the other hand, a positive correlation was only noted between the titres of tissue-reacting immunoglobulins and the migration indices induced by brain antigens: when titres of tissue-reacting immunoglobulins were elevated, less leucocyte migration inhibition was detected.
采用直接白细胞迁移抑制试验，对31例慢性感染克氏锥虫的无症状者和23例正常未感染者进行了研究。所用抗原制剂由小鼠和豚鼠的心脏、骨骼肌、肾脏、肝脏及脑制成。在寄生虫感染者中，对肾脏、肝脏和脑抗原出现阳性反应，但对骨骼肌组织心脏制备的抗原无阳性反应。未发现克氏锥虫抗体滴度与针对这些不同抗原的迁移指数值之间存在相关性。另一方面，仅在组织反应性免疫球蛋白滴度与脑抗原诱导的迁移指数之间发现正相关：当组织反应性免疫球蛋白滴度升高时，检测到的白细胞迁移抑制作用减弱。
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