Anaplastic carcinoma in the buccal pouches of hamsters as a model of oral cancer.

An anaplastic model of oral cancer has been developed by abdominal transplantation of carcinomas induced in buccal pouches of hamsters by DMBA. The transplanted tumors were replanted abdominally through five generations. The original carcinomas of the buccal pouch became stable in the abdomen after two generations of such transplantations and could thereafter be retransplanted intraperitoneally with 100% of success, as well as being transferable again to the buccal pouches of hamsters, where they were capable of being maintained as an oral model for anaplastic epidermoid carcinoma.