Käpyaho K, Linnamaa K, Jänne J
J Invest Dermatol. 1982 May;78(5):391-4. doi: 10.1111/1523-1747.ep12507519.
A systemic or topical treatment of mice with alpha-difluoromethylornithine, and irreversible inhibitor of mammalian ornithine decarboxylase, produced a rapid depletion of epidermal putrescine and spermidine. When methylglyoxal bis(guanylhydrazone), another inhibitor of polyamine biosynthesis and a potent antiproliferative agent, was subsequently administered the epidermal concentration of the latter drug rose distinctly higher than without a prior difluoromethyl ornithine treatment. The combined use of these 2 antimetabolites of polyamines also profoundly depressed epidermal DNA synthesis, especially in UV-irradiated skin. A "priming" with difluoromethyl ornithine may therefore offer a means to enhance the epidermal accumulation of otherwise poorly absorbed methylglyoxal bis(guanylhydrazone).
用α-二氟甲基鸟氨酸（一种哺乳动物鸟氨酸脱羧酶的不可逆抑制剂）对小鼠进行全身或局部治疗，会使表皮腐胺和亚精胺迅速耗竭。随后给予甲基乙二醛双（脒腙）（另一种多胺生物合成抑制剂和强效抗增殖剂）时，后一种药物在表皮中的浓度明显高于未预先用二氟甲基鸟氨酸治疗的情况。这两种多胺抗代谢物联合使用也会显著抑制表皮DNA合成，尤其是在紫外线照射的皮肤中。因此，用二氟甲基鸟氨酸进行“预处理”可能提供一种方法来增强原本吸收不良的甲基乙二醛双（脒腙）在表皮中的蓄积。
