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[未麻醉动物胆碱能血管舒张的药理学分析]

[Pharmacologic analysis of the cholinergic vasodilation in unanesthetized animals].

作者信息

Dorokhova M I

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1978 Jul;64(7):990-8.

PMID:680291
Abstract

Cholinergic vasodilatation evoked by hypothalamic stimulation in cats could be elicited by stimulation of both the emotional and mator areas of the brain. Tranquilizers affected the cholinergic vasodilatation in different ways: reserpine decreased, catapresan increased, while diazepam had no effect on amplitude of the cholinergic vasodilatation. The latter seems to be closely connected with activity of skeletal muscles but not with emotional reactions. Alpha--adrenergic structures of the c. n. s. are the activating mechanism of the central integration of cholinergic vasodilatation.

摘要

猫下丘脑刺激诱发的胆碱能血管舒张可通过刺激大脑的情感区和运动区引发。镇静剂对胆碱能血管舒张有不同影响:利血平使其降低,可乐定使其增加,而地西泮对胆碱能血管舒张幅度无影响。后者似乎与骨骼肌活动密切相关,而与情感反应无关。中枢神经系统的α-肾上腺素能结构是胆碱能血管舒张中枢整合的激活机制。

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